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Fluorine effect in nucleophilic fluorination at C4 of 1,6-anhydro-2,3-dideoxy-2,3-difluoro-β-D-hexopyranose

In this work, we have developed a simple synthetic approach using Et(3)N·3HF as an alternative to the DAST reagent. We controlled the stereochemistry of the nucleophilic fluorination at C4 of 1,6-anhydro-2,3-dideoxy-2,3-difluoro-4-O-triflate-β-ᴅ-talopyranose using Et(3)N·3HF or in situ generated Et(...

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Detalles Bibliográficos
Autores principales:	Lainé, Danny, Denavit, Vincent, Lessard, Olivier, Carrier, Laurie, Fecteau, Charles-Émile, Johnson, Paul A, Giguère, Denis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2020
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705882/ https://www.ncbi.nlm.nih.gov/pubmed/33299486 http://dx.doi.org/10.3762/bjoc.16.237

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