On-Demand Detachment of Succinimides on Cysteine to Facilitate (Semi)Synthesis of Challenging Proteins

[Image: see text] The maleimide group is a widely used reagent for bioconjugation of peptides, proteins, and oligonucleotides employing Michael addition and Diels–Alder cycloaddition reactions. However, the utility of this functionality in chemical synthesis of peptides and proteins remains unexplor...

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Detalles Bibliográficos
Autores principales: Vamisetti, Ganga B., Satish, Gandhesiri, Sulkshane, Prasad, Mann, Guy, Glickman, Michael H., Brik, Ashraf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705887/
https://www.ncbi.nlm.nih.gov/pubmed/33136379
http://dx.doi.org/10.1021/jacs.0c07663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705887/
https://www.ncbi.nlm.nih.gov/pubmed/33136379
http://dx.doi.org/10.1021/jacs.0c07663

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