Mechanochemical Synthesis and Physicochemical Characterization of Isoniazid and Pyrazinamide Co-crystals With Glutaric Acid

The present work reports two novel pharmaceutical co-crystals; 2:1 isoniazid-glutaric acid (INHGA) and 2:1 pyrazinamide-glutaric acid (PGA). Isoniazid and pyrazinamide are key first-line drugs used for the treatment of tuberculosis. The co-crystals were produced via solid-state and solvent assisted...

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Detalles Bibliográficos
Autores principales: Ngilirabanga, Jean Baptiste, Aucamp, Marique, Pires Rosa, Paulo, Samsodien, Halima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706006/
https://www.ncbi.nlm.nih.gov/pubmed/33282840
http://dx.doi.org/10.3389/fchem.2020.595908

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706006/
https://www.ncbi.nlm.nih.gov/pubmed/33282840
http://dx.doi.org/10.3389/fchem.2020.595908

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