Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease

Graft-versus-host disease (GVHD) limits the success of allogeneic hematopoietic cell transplantation (allo-HCT). Lysosomal acid lipase (LAL) mediates the intrinsic lipolysis of cells to generate free fatty acids (FFAs), which play an essential role in the development, proliferation, and function of...

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Detalles Bibliográficos
Autores principales: Nguyen, Hung D., Ticer, Taylor, Bastian, David, Kuril, Sandeepkumar, Li, Hong, Du, Hong, Yan, Cong, Yu, Xue-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706352/
https://www.ncbi.nlm.nih.gov/pubmed/33113360
http://dx.doi.org/10.1016/j.celrep.2020.108316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706352/
https://www.ncbi.nlm.nih.gov/pubmed/33113360
http://dx.doi.org/10.1016/j.celrep.2020.108316

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