Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore

Mutations in the telomere-binding protein POT1 are associated with solid tumors and leukemias. POT1 alterations cause rapid telomere elongation, ATR kinase activation, telomere fragility, and accelerated tumor development. Here, we define the impact of mutant POT1 alleles through complementary genet...

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Detalles Bibliográficos
Autores principales: Pinzaru, Alexandra M., Kareh, Mike, Lamm, Noa, Lazzerini-Denchi, Eros, Cesare, Anthony J., Sfeir, Agnel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706707/
https://www.ncbi.nlm.nih.gov/pubmed/33122293
http://dx.doi.org/10.1101/gad.337287.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706707/
https://www.ncbi.nlm.nih.gov/pubmed/33122293
http://dx.doi.org/10.1101/gad.337287.120

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