Loss of histone H3.3 results in DNA replication defects and altered origin dynamics in C. elegans

Histone H3.3 is a replication-independent variant of histone H3 with important roles in development, differentiation, and fertility. Here, we show that loss of H3.3 results in replication defects in Caenorhabditis elegans embryos at elevated temperatures. To characterize these defects, we adapt meth...

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Detalles Bibliográficos
Autores principales: Strobino, Maude, Wenda, Joanna M., Padayachy, Laura, Steiner, Florian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706726/
https://www.ncbi.nlm.nih.gov/pubmed/33172964
http://dx.doi.org/10.1101/gr.260794.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706726/
https://www.ncbi.nlm.nih.gov/pubmed/33172964
http://dx.doi.org/10.1101/gr.260794.120

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