Discovery and characterization of ORM‐11372, a novel inhibitor of the sodium‐calcium exchanger with positive inotropic activity

BACKGROUND AND PURPOSE: The lack of selective sodium–calcium exchanger (NCX) inhibitors has hampered the exploration of physiological and pathophysiological roles of cardiac NCX 1.1. We aimed to discover more potent and selective drug like NCX 1.1 inhibitor. EXPERIMENTAL APPROACH: A flavan series‐ba...

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Detalles Bibliográficos
Autores principales: Otsomaa, Leena, Levijoki, Jouko, Wohlfahrt, Gerd, Chapman, Hugh, Koivisto, Ari‐Pekka, Syrjänen, Kaisa, Koskelainen, Tuula, Peltokorpi, Saara‐Elisa, Finckenberg, Piet, Heikkilä, Aira, Abi‐Gerges, Najah, Ghetti, Andre, Miller, Paul E., Page, Guy, Mervaala, Eero, Nagy, Norbert, Kohajda, Zsófia, Jost, Norbert, Virág, László, Varró, András, Papp, Julius Gy.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707092/
https://www.ncbi.nlm.nih.gov/pubmed/32959887
http://dx.doi.org/10.1111/bph.15257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707092/
https://www.ncbi.nlm.nih.gov/pubmed/32959887
http://dx.doi.org/10.1111/bph.15257

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