The anti-tubercular activity of simvastatin is mediated by cholesterol-driven autophagy via the AMPK-mTORC1-TFEB axis

The rise of drug-resistant tuberculosis poses a major risk to public health. Statins, which inhibit both cholesterol biosynthesis and protein prenylation branches of the mevalonate pathway, increase anti-tubercular antibiotic efficacy in animal models. However, the underlying molecular mechanisms ar...

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Detalles Bibliográficos
Autores principales: Bruiners, Natalie, Dutta, Noton K., Guerrini, Valentina, Salamon, Hugh, Yamaguchi, Ken D., Karakousis, Petros C., Gennaro, Maria L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707180/
https://www.ncbi.nlm.nih.gov/pubmed/32848049
http://dx.doi.org/10.1194/jlr.RA120000895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707180/
https://www.ncbi.nlm.nih.gov/pubmed/32848049
http://dx.doi.org/10.1194/jlr.RA120000895

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