Natural history study of glycan accumulation in large animal models of GM2 gangliosidoses

β-hexosaminidase is an enzyme responsible for the degradation of gangliosides, glycans, and other glycoconjugates containing β-linked hexosamines that enter the lysosome. GM2 gangliosidoses, such as Tay-Sachs and Sandhoff, are lysosomal storage disorders characterized by β-hexosaminidase deficiency...

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Detalles Bibliográficos
Autores principales: Cavender, Catlyn, Mangini, Linley, Van Vleet, Jeremy L., Corado, Carley, McCullagh, Emma, Gray-Edwards, Heather L., Martin, Douglas R., Crawford, Brett E., Lawrence, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707493/
https://www.ncbi.nlm.nih.gov/pubmed/33259552
http://dx.doi.org/10.1371/journal.pone.0243006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707493/
https://www.ncbi.nlm.nih.gov/pubmed/33259552
http://dx.doi.org/10.1371/journal.pone.0243006

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