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The crystal structure of mouse IRG1 suggests that cis-aconitate decarboxylase has an open and closed conformation
Itaconate, produced as an offshoot of the TCA cycle, is a multifunctional immunometabolite possessing antibacterial, antiviral, immune regulation, and tumor progression activities. The production of itaconate in biological systems is catalyzed by cis-aconitate decarboxylase (CAD, also known as immun...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707506/ https://www.ncbi.nlm.nih.gov/pubmed/33259501 http://dx.doi.org/10.1371/journal.pone.0242383 |