Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells

Glioblastoma is the most common and aggressive type of cancer in the brain; its poor prognosis is often marked by reoccurrence due to resistance to the chemotherapeutic agent temozolomide, which is triggered by an increase in the expression of DNA repair enzymes such as MGMT. The poor prognosis and...

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Detalles Bibliográficos
Autores principales: Lafita-Navarro, M. Carmen, Venkateswaran, Niranjan, Kilgore, Jessica A., Kanji, Suman, Han, Jungsoo, Barnes, Spencer, Williams, Noelle S., Buszczak, Michael, Burma, Sandeep, Conacci-Sorrell, Maralice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707548/
https://www.ncbi.nlm.nih.gov/pubmed/33201894
http://dx.doi.org/10.1371/journal.pgen.1009117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707548/
https://www.ncbi.nlm.nih.gov/pubmed/33201894
http://dx.doi.org/10.1371/journal.pgen.1009117

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