TINF2 is a haploinsufficient tumor suppressor that limits telomere length

Telomere shortening is a presumed tumor suppressor pathway that imposes a proliferative barrier (the Hayflick limit) during tumorigenesis. This model predicts that excessively long somatic telomeres predispose to cancer. Here, we describe cancer-prone families with two unique TINF2 mutations that tr...

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Detalles Bibliográficos
Autores principales: Schmutz, Isabelle, Mensenkamp, Arjen R, Takai, Kaori K, Haadsma, Maaike, Spruijt, Liesbeth, de Voer, Richarda M, Choo, Seunga Sara, Lorbeer, Franziska K, van Grinsven, Emma J, Hockemeyer, Dirk, Jongmans, Marjolijn CJ, de Lange, Titia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707837/
https://www.ncbi.nlm.nih.gov/pubmed/33258446
http://dx.doi.org/10.7554/eLife.61235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707837/
https://www.ncbi.nlm.nih.gov/pubmed/33258446
http://dx.doi.org/10.7554/eLife.61235

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