Deletion of Akt1 Promotes Kidney Fibrosis in a Murine Model of Unilateral Ureteral Obstruction

We investigated the role of Akt1, one of the three isoforms of Akt, in renal fibrosis using the murine model of unilateral ureteral obstruction (UUO). We subjected wild type and Akt1(−/−) mice to UUO. The Akt1 gene was silenced in vitro using short hairpin RNA delivered via a lentiviral vector in hu...

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Detalles Bibliográficos
Autores principales: Kim, Il Young, Lee, Min Young, Park, Mi Wha, Seong, Eun Young, Lee, Dong Won, Lee, Soo Bong, Bae, Sun Sik, Kim, Sang Soo, Song, Sang Heon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707954/
https://www.ncbi.nlm.nih.gov/pubmed/33299873
http://dx.doi.org/10.1155/2020/6143542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707954/
https://www.ncbi.nlm.nih.gov/pubmed/33299873
http://dx.doi.org/10.1155/2020/6143542

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