Benzo[a]pyrene represses DNA repair through altered E2F1/E2F4 function marking an early event in DNA damage-induced cellular senescence

Transcriptional regulation of DNA repair is of outmost importance for the restoration of DNA integrity upon genotoxic stress. Here we report that the potent environmental carcinogen benzo[a]pyrene (B[a]P) activates a cellular DNA damage response resulting in transcriptional repression of mismatch re...

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Detalles Bibliográficos
Autores principales: Allmann, Sebastian, Mayer, Laura, Olma, Jessika, Kaina, Bernd, Hofmann, Thomas G, Tomicic, Maja T, Christmann, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708059/
https://www.ncbi.nlm.nih.gov/pubmed/33166399
http://dx.doi.org/10.1093/nar/gkaa965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708059/
https://www.ncbi.nlm.nih.gov/pubmed/33166399
http://dx.doi.org/10.1093/nar/gkaa965

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