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A robust CRISPR–Cas9-based fluorescent reporter assay for the detection and quantification of DNA double-strand break repair
DNA double-strand breaks (DSBs) are highly cytotoxic lesions that can lead to chromosome rearrangements, genomic instability and cell death. Consequently, cells have evolved multiple mechanisms to efficiently repair DSBs to preserve genomic integrity. We have developed a DSB repair assay system, des...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708081/ https://www.ncbi.nlm.nih.gov/pubmed/33068408 http://dx.doi.org/10.1093/nar/gkaa897 |