Network and pathway expansion of genetic disease associations identifies successful drug targets

Genetic evidence of disease association has often been used as a basis for selecting of drug targets for complex common diseases. Likewise, the propagation of genetic evidence through gene or protein interaction networks has been shown to accurately infer novel disease associations at genes for whic...

Descripción completa

Detalles Bibliográficos
Autores principales: MacNamara, Aidan, Nakic, Nikolina, Amin Al Olama, Ali, Guo, Cong, Sieber, Karsten B., Hurle, Mark R., Gutteridge, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708424/
https://www.ncbi.nlm.nih.gov/pubmed/33262371
http://dx.doi.org/10.1038/s41598-020-77847-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708424/
https://www.ncbi.nlm.nih.gov/pubmed/33262371
http://dx.doi.org/10.1038/s41598-020-77847-9

Ejemplares similares