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Multiple proteases are involved in mesothelin shedding by cancer cells

Mesothelin (MSLN) is a lineage restricted cell surface protein expressed in about 30% of human cancers and high MSLN expression is associated with poor survival in several different cancers. The restricted expression of MSLN in normal tissue and its frequent expression in cancers make MSLN an excell...

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Detalles Bibliográficos
Autores principales: Liu, Xiufen, Chan, Alexander, Tai, Chin-Hsien, Andresson, Thorkell, Pastan, Ira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708464/
https://www.ncbi.nlm.nih.gov/pubmed/33262421
http://dx.doi.org/10.1038/s42003-020-01464-5