High throughput profiling of undifferentiated pleomorphic sarcomas identifies two main subgroups with distinct immune profile, clinical outcome and sensitivity to targeted therapies

BACKGROUND: Undifferentiated pleomorphic sarcoma (UPS) is the most frequent, aggressive and less-characterized sarcoma subtype. This study aims to assess UPS molecular characteristics and identify specific therapeutic targets. METHODS: High-throughput technologies encompassing immunohistochemistry,...

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Detalles Bibliográficos
Autores principales: Toulmonde, Maud, Lucchesi, Carlo, Verbeke, Stéphanie, Crombe, Amandine, Adam, Julien, Geneste, Damien, Chaire, Vanessa, Laroche-Clary, Audrey, Perret, Raul, Bertucci, François, Bertolo, Frederic, Bianchini, Laurence, Dadone-Montaudie, Bérengère, Hembrough, Todd, Sweet, Steve, Kim, Yeoun Jin, Cecchi, Fabiola, Le Loarer, François, Italiano, Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708794/
https://www.ncbi.nlm.nih.gov/pubmed/33254023
http://dx.doi.org/10.1016/j.ebiom.2020.103131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708794/
https://www.ncbi.nlm.nih.gov/pubmed/33254023
http://dx.doi.org/10.1016/j.ebiom.2020.103131

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