Taking the Hinge off: An Approach to Effector-Less Monoclonal Antibodies

A variety of Fc domain engineering approaches for abrogating the effector functions of mAbs exists. To address some of the limitations of the current Fc domain silencing approaches, we are exploring a less commonly considered option which relies on the deletion of the hinge. Removal of the hinge dom...

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Detalles Bibliográficos
Autores principales: Valeich, Jamie, Boyd, Dan, Kanwar, Manu, Stenzel, Daniel, De Ghosh, Deblina, Ebrahimi, Arpa, Woo, James, Wang, Jenny, Ambrogelly, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709103/
https://www.ncbi.nlm.nih.gov/pubmed/32977708
http://dx.doi.org/10.3390/antib9040050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709103/
https://www.ncbi.nlm.nih.gov/pubmed/32977708
http://dx.doi.org/10.3390/antib9040050

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