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Taking the Hinge off: An Approach to Effector-Less Monoclonal Antibodies
A variety of Fc domain engineering approaches for abrogating the effector functions of mAbs exists. To address some of the limitations of the current Fc domain silencing approaches, we are exploring a less commonly considered option which relies on the deletion of the hinge. Removal of the hinge dom...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709103/ https://www.ncbi.nlm.nih.gov/pubmed/32977708 http://dx.doi.org/10.3390/antib9040050 |