Crystal Structure and Characterization of Human Heavy-Chain Only Antibodies Reveals a Novel, Stable Dimeric Structure Similar to Monoclonal Antibodies

We report the novel crystal structure and characterization of symmetrical, homodimeric humanized heavy-chain-only antibodies or dimers (HC2s). HC2s were found to be significantly coexpressed and secreted along with mAbs from transient CHO HC/LC cotransfection, resulting in an unacceptable mAb develo...

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Detalles Bibliográficos
Autores principales: Mieczkowski, Carl, Bahmanjah, Soheila, Yu, Yao, Baker, Jeanne, Raghunathan, Gopalan, Tomazela, Daniela, Hsieh, Mark, McCoy, Mark, Strickland, Corey, Fayadat-Dilman, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709113/
https://www.ncbi.nlm.nih.gov/pubmed/33266498
http://dx.doi.org/10.3390/antib9040066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709113/
https://www.ncbi.nlm.nih.gov/pubmed/33266498
http://dx.doi.org/10.3390/antib9040066

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