Fc-Engineering for Modulated Effector Functions—Improving Antibodies for Cancer Treatment

The majority of monoclonal antibody (mAb) therapeutics possess the ability to engage innate immune effectors through interactions mediated by their fragment crystallizable (Fc) domain. By delivering Fc-Fc gamma receptor (FcγR) and Fc-C1q interactions, mAb are able to link exquisite specificity to po...

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Detalles Bibliográficos
Autores principales: Liu, Rena, Oldham, Robert J., Teal, Emma, Beers, Stephen A., Cragg, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709126/
https://www.ncbi.nlm.nih.gov/pubmed/33212886
http://dx.doi.org/10.3390/antib9040064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709126/
https://www.ncbi.nlm.nih.gov/pubmed/33212886
http://dx.doi.org/10.3390/antib9040064

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