Natural Killer (NK) Cell Expression of CD2 as a Predictor of Serial Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)

NK cell ADCC supports monoclonal antibody anti-tumor therapies. We investigated serial ADCC and whether it could be predicted by NK phenotypes, including expression of CD16A, CD2 and perforin. CD16A, the NK receptor for antibodies, has AA158 valine or phenylalanine variants with different affinities...

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Detalles Bibliográficos
Autores principales: Tang, Jennifer J.-J., Sung, Alexander P., Guglielmo, Michael J., Navarrete-Galvan, Lydia, Redelman, Doug, Smith-Gagen, Julie, Hudig, Dorothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709134/
https://www.ncbi.nlm.nih.gov/pubmed/33081115
http://dx.doi.org/10.3390/antib9040054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709134/
https://www.ncbi.nlm.nih.gov/pubmed/33081115
http://dx.doi.org/10.3390/antib9040054

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