Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment

BACKGROUND: Chronic cerebral hypoperfusion causes damage to the brain’s white matter underpinning vascular cognitive impairment. Inflammation and oxidative stress have been proposed as key pathophysiological mechanisms of which the transcription factor Nrf2 is a master regulator. We hypothesised tha...

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Detalles Bibliográficos
Autores principales: Sigfridsson, Emma, Marangoni, Martina, Hardingham, Giles E., Horsburgh, Karen, Fowler, Jill H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709339/
https://www.ncbi.nlm.nih.gov/pubmed/33261626
http://dx.doi.org/10.1186/s12974-020-02038-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709339/
https://www.ncbi.nlm.nih.gov/pubmed/33261626
http://dx.doi.org/10.1186/s12974-020-02038-2

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