Cargando…

Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment

BACKGROUND: Chronic cerebral hypoperfusion causes damage to the brain’s white matter underpinning vascular cognitive impairment. Inflammation and oxidative stress have been proposed as key pathophysiological mechanisms of which the transcription factor Nrf2 is a master regulator. We hypothesised tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sigfridsson, Emma, Marangoni, Martina, Hardingham, Giles E., Horsburgh, Karen, Fowler, Jill H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709339/ https://www.ncbi.nlm.nih.gov/pubmed/33261626 http://dx.doi.org/10.1186/s12974-020-02038-2

Ejemplares similares

Astrocyte-specific overexpression of Nrf2 protects against optic tract damage and behavioural alterations in a mouse model of cerebral hypoperfusion
por: Sigfridsson, Emma, et al.
Publicado: (2018)

Dimethyl fumarate improves white matter function following severe hypoperfusion: Involvement of microglia/macrophages and inflammatory mediators
por: Fowler, Jill H, et al.
Publicado: (2017)

Activation of Nrf2-Regulated Glutathione Pathway Genes by Ischemic Preconditioning
por: Bell, Karen F. S., et al.
Publicado: (2011)

Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype
por: Matsudaira, Tatsuyuki, et al.
Publicado: (2023)

Depletion of Arg1-Positive Microglia/Macrophages Exacerbates Cerebral Ischemic Damage by Facilitating the Inflammatory Response
por: Li, Ting, et al.
Publicado: (2022)

Microglial SIRPα regulates the emergence of CD11c(+) microglia and demyelination damage in white matter
por: Sato-Hashimoto, Miho, et al.
Publicado: (2019)

Comparative Aspects of Microglia Reaction in White and Gray Matter
por: Cătălin, B., et al.
Publicado: (2013)

Unique microglia expression profile in developing white matter
por: Staszewski, Ori, et al.
Publicado: (2019)

Heterogeneity of microglia and their differential roles in white matter pathology
por: Lee, Janice, et al.
Publicado: (2019)

Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion
por: Zhang, Lin-Yuan, et al.
Publicado: (2020)

Loss of USP18 in microglia induces white matter pathology
por: Schwabenland, Marius, et al.
Publicado: (2019)

Modified exosomal SIRPα variants alleviate white matter injury after intracerebral hemorrhage via microglia/macrophages
por: Gao, Xinjie, et al.
Publicado: (2022)

Endothelial damage, vascular bagging and remodeling of the microvascular bed in human microangiopathy with deep white matter lesions
por: Forsberg, Karin M. E., et al.
Publicado: (2018)

Deficiency of tPA Exacerbates White Matter Damage, Neuroinflammation, Glymphatic Dysfunction and Cognitive Dysfunction in Aging Mice
por: Yu, Peng, et al.
Publicado: (2019)

Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration
por: Gupta, Kunal, et al.
Publicado: (2013)

CD8(+) T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging
por: Kaya, Tuğberk, et al.
Publicado: (2022)

Ultrastructural pathology of oligodendrocytes adjacent to microglia in prefrontal white matter in schizophrenia
por: Uranova, Natalya A., et al.
Publicado: (2018)

Activated Microglia in Cortical White Matter Across Cognitive Aging Trajectories
por: Gefen, Tamar, et al.
Publicado: (2019)

The Role of Microglia in Inherited White-Matter Disorders and Connections to Frontotemporal Dementia
por: Sirkis, Daniel W, et al.
Publicado: (2021)

Vascular incontinence: incontinence in the elderly due to ischemic white matter changes
por: Sakakibara, Ryuji, et al.
Publicado: (2012)

Low-Fat Diet With Caloric Restriction Reduces White Matter Microglia Activation During Aging
por: Yin, Zhuoran, et al.
Publicado: (2018)

Transplantation of iPS‐derived vascular endothelial cells improves white matter ischemic damage
por: Xu, Bin, et al.
Publicado: (2020)

White matter damage due to vascular, tau, and TDP-43 pathologies and its relevance to cognition
por: Raghavan, Sheelakumari, et al.
Publicado: (2022)

Differential perivascular microglial activation in the deep white matter in vascular dementia developed post‐stroke
por: Hase, Yoshiki, et al.
Publicado: (2022)

Senescent and disease-associated microglia are modifiable features of aged brain white matter
por: Carver, Chase M., et al.
Publicado: (2023)

Pathophysiology of white matter perfusion in Alzheimer’s disease and vascular dementia
por: Barker, Rachel, et al.
Publicado: (2014)

Ambroxol Improves Neuronal Survival and Reduces White Matter Damage through Suppressing Endoplasmic Reticulum Stress in Microglia after Intracerebral Hemorrhage
por: Jiang, Xuheng, et al.
Publicado: (2020)

Caffeine treatment started before injury reduces hypoxic–ischemic white-matter damage in neonatal rats by regulating phenotypic microglia polarization
por: Yang, Liu, et al.
Publicado: (2022)

Activation of Nrf2 to Optimise Immune Responses to Intracerebral Haemorrhage
por: Loan, James J. M., et al.
Publicado: (2022)

Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes
por: Hegdekar, Nivedita, et al.
Publicado: (2023)

Function of microglia and macrophages in secondary damage after spinal cord injury
por: Zhou, Xiang, et al.
Publicado: (2014)

White matter capillaries in vascular and neurodegenerative dementias
por: Hase, Yoshiki, et al.
Publicado: (2019)

White Matter Damage in the Cholinergic System Contributes to Cognitive Impairment in Subcortical Vascular Cognitive Impairment, No Dementia
por: Liu, Qing, et al.
Publicado: (2017)

Corrigendum to “Ambroxol Improves Neuronal Survival and Reduces White Matter Damage through Suppressing Endoplasmic Reticulum Stress in Microglia after Intracerebral Hemorrhage”
por: Jiang, Xuheng, et al.
Publicado: (2020)

Measuring Gray Matter and White Matter Damage in MS: Why This is Not Enough
por: Enzinger, Christian, et al.
Publicado: (2015)

Significance and In Vivo Detection of Iron-Laden Microglia in White Matter Multiple Sclerosis Lesions
por: Gillen, Kelly M., et al.
Publicado: (2018)

CD11c(+) microglia promote white matter repair after ischemic stroke
por: Jia, Junqiu, et al.
Publicado: (2023)

Delayed Hypoxemia Following Traumatic Brain Injury Exacerbates White Matter Injury
por: Parikh, Umang, et al.
Publicado: (2016)

Mechanism underlying the protective effect of Kaixin Jieyu Fang on vascular depression following cerebral white matter damage
por: Zhang, Ying, et al.
Publicado: (2014)

Implications of white matter damage in amyotrophic lateral sclerosis
por: Zhou, Ting, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_tdr7rfen3v0lc29kbipgbcvdf8