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Mutant p53 drives the loss of heterozygosity by the upregulation of Nek2 in breast cancer cells
BACKGROUND: Mutations in one allele of the TP53 gene in early stages are frequently followed by the loss of the remaining wild-type p53 (wtp53) allele (p53LOH) during tumor progression. Despite the strong notion of p53LOH as a critical step in tumor progression, its oncogenic outcomes that facilitat...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709447/ https://www.ncbi.nlm.nih.gov/pubmed/33267874 http://dx.doi.org/10.1186/s13058-020-01370-y |