L-type voltage-gated calcium channel agonists mitigate hearing loss and modify ribbon synapse morphology in the zebrafish model of Usher syndrome type 1

The mariner (myo7aa(−/−)) mutant is a zebrafish model for Usher syndrome type 1 (USH1). To further characterize hair cell synaptic elements in myo7aa(−/−) mutants, we focused on the ribbon synapse and evaluated ultrastructure, number and distribution of immunolabeled ribbons, and postsynaptic densit...

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Detalles Bibliográficos
Autores principales: Koleilat, Alaa, Dugdale, Joseph A., Christenson, Trace A., Bellah, Jeffrey L., Lambert, Aaron M., Masino, Mark A., Ekker, Stephen C., Schimmenti, Lisa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710014/
https://www.ncbi.nlm.nih.gov/pubmed/33361086
http://dx.doi.org/10.1242/dmm.043885

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710014/
https://www.ncbi.nlm.nih.gov/pubmed/33361086
http://dx.doi.org/10.1242/dmm.043885

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