Refinement of the CS6-expressing enterotoxigenic Escherichia coli strain B7A human challenge model: A randomized trial

BACKGROUND: Human challenge models for enterotoxigenic Escherichia coli (ETEC) facilitate vaccine down-selection. The B7A (O148:H28 CS6(+)LT(+)ST(+)) strain is important for vaccine development. We sought to refine the B7A model by identifying a dose and fasting regimen consistently inducing moderat...

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Detalles Bibliográficos
Autores principales: Talaat, Kawsar R., Porter, Chad K., Jaep, Kayla M., Duplessis, Christopher A., Gutierrez, Ramiro L., Maciel, Milton, Adjoodani, Brittany, Feijoo, Brittany, Chakraborty, Subhra, Brubaker, Jessica, Trop, Stefanie A., Riddle, Mark S., Joseph, Sabrina S., Bourgeois, A. Louis, Prouty, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710093/
https://www.ncbi.nlm.nih.gov/pubmed/33264302
http://dx.doi.org/10.1371/journal.pone.0239888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710093/
https://www.ncbi.nlm.nih.gov/pubmed/33264302
http://dx.doi.org/10.1371/journal.pone.0239888

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