Cargando…

Refinement of the CS6-expressing enterotoxigenic Escherichia coli strain B7A human challenge model: A randomized trial

BACKGROUND: Human challenge models for enterotoxigenic Escherichia coli (ETEC) facilitate vaccine down-selection. The B7A (O148:H28 CS6(+)LT(+)ST(+)) strain is important for vaccine development. We sought to refine the B7A model by identifying a dose and fasting regimen consistently inducing moderat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Talaat, Kawsar R., Porter, Chad K., Jaep, Kayla M., Duplessis, Christopher A., Gutierrez, Ramiro L., Maciel, Milton, Adjoodani, Brittany, Feijoo, Brittany, Chakraborty, Subhra, Brubaker, Jessica, Trop, Stefanie A., Riddle, Mark S., Joseph, Sabrina S., Bourgeois, A. Louis, Prouty, Michael G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710093/ https://www.ncbi.nlm.nih.gov/pubmed/33264302 http://dx.doi.org/10.1371/journal.pone.0239888

Ejemplares similares

Oral delivery of Hyperimmune bovine serum antibodies against CS6-expressing enterotoxigenic Escherichia coli as a prophylactic against diarrhea
por: Talaat, KR, et al.
Publicado: (2020)

Safety and immunogenicity of intramuscularly administered CS6 subunit vaccine with a modified heat-labile enterotoxin from enterotoxigenic Escherichia coli
por: Lee, Tida, et al.
Publicado: (2021)

Immune response characterization in a human challenge study with a Shigella flexneri 2a bioconjugate vaccine
por: Clarkson, Kristen A., et al.
Publicado: (2021)

Human challenge study with a Shigella bioconjugate vaccine: Analyses of clinical efficacy and correlate of protection
por: Talaat, Kawsar R., et al.
Publicado: (2021)

Clinical endpoints in the controlled human challenge model for Shigella: A call for standardization and the development of a disease severity score
por: Porter, Chad K., et al.
Publicado: (2018)

Intestinal and systemic inflammation induced by symptomatic and asymptomatic enterotoxigenic E. coli infection and impact on intestinal colonization and ETEC specific immune responses in an experimental human challenge model
por: Brubaker, Jessica, et al.
Publicado: (2021)

Impact of lower challenge doses of enterotoxigenic Escherichia coli on clinical outcome, intestinal colonization and immune responses in adult volunteers
por: Chakraborty, Subhra, et al.
Publicado: (2018)

Development of a novel multiplex electrochemiluminescent-based immunoassay to aid enterotoxigenic Escherichia coli vaccine development and evaluations
por: Chakraborty, Subhra, et al.
Publicado: (2019)

Consensus Report on Shigella Controlled Human Infection Model: Conduct of Studies
por: Talaat, Kawsar R, et al.
Publicado: (2019)

A First in Human Clinical Trial Assessing the Safety and Immunogenicity of Two Intradermally Delivered Enterotoxigenic Escherichia coli CFA/I Fimbrial Tip Adhesin Antigens with and without Heat-Labile Enterotoxin with Mutation LT(R192G)
por: Gutiérrez, Ramiro L., et al.
Publicado: (2023)

Cross-Reactivity, Epitope Mapping, and Potency of Monoclonal Antibodies to Class 5 Fimbrial Tip Adhesins of Enterotoxigenic Escherichia coli
por: Liu, Yang, et al.
Publicado: (2020)

Development and Comparison of a Panel of Modified CS17 Fimbrial Tip Adhesin Proteins as Components for an Adhesin-Based Vaccine against Enterotoxigenic Escherichia coli
por: Liu, Yang, et al.
Publicado: (2021)

Campylobacter jejuni transcriptional and genetic adaptation during human infection
por: Crofts, Alexander A., et al.
Publicado: (2018)

Live attenuated enterotoxigenic Escherichia coli (ETEC) vaccine with dmLT adjuvant protects human volunteers against virulent experimental ETEC challenge
por: Harro, Clayton, et al.
Publicado: (2019)

Consensus Report on Shigella Controlled Human Infection Model: Clinical Endpoints
por: MacLennan, Calman A, et al.
Publicado: (2019)

Human immune responses against Shigella and enterotoxigenic E. coli: Current advances and the path forward
por: McArthur, Monica A., et al.
Publicado: (2017)

Interrogation of a live-attenuated enterotoxigenic Escherichia coli vaccine highlights features unique to wild-type infection
por: Chakraborty, Subhra, et al.
Publicado: (2019)

Antibody-mediated disruption of the mechanics of CS20 fimbriae of enterotoxigenic Escherichia coli
por: Singh, Bhupender, et al.
Publicado: (2015)

Sulfatide Recognition by Colonization Factor Antigen CS6 from Enterotoxigenic Escherichia coli
por: Jansson, Lena, et al.
Publicado: (2009)

Seroprevalence Study of Conserved Enterotoxigenic Escherichia coli Antigens in Globally Diverse Populations
por: Kuhlmann, Frederick Matthew, et al.
Publicado: (2023)

A Polyvalent Adhesin–Toxoid Multiepitope-Fusion-Antigen-Induced Functional Antibodies against Five Enterotoxigenic Escherichia coli Adhesins (CS7, CS12, CS14, CS17, and CS21) but Not Enterotoxins (LT and STa)
por: Li, Siqi, et al.
Publicado: (2023)

Adjuvant effect of enterotoxigenic Escherichia coli (ETEC) double-mutant heat-labile toxin (dmLT) on systemic immunogenicity induced by the CFA/I/II/IV MEFA ETEC vaccine: Dose-related enhancement of antibody responses to seven ETEC adhesins (CFA/I, CS1-CS6)
por: Seo, Hyesuk, et al.
Publicado: (2019)

Circulation of enterotoxigenic Escherichia coli (ETEC) isolates expressing CS23 from the environment to clinical settings
por: Calderon Toledo, Carla, et al.
Publicado: (2023)

Shigella-Specific Immune Profiles Induced after Parenteral Immunization or Oral Challenge with Either Shigella flexneri 2a or Shigella sonnei
por: Clarkson, Kristen A., et al.
Publicado: (2021)

Effects of lng Mutations on LngA Expression, Processing, and CS21 Assembly in Enterotoxigenic Escherichia coli E9034A
por: Saldaña-Ahuactzi, Zeus, et al.
Publicado: (2016)

A putative, novel coli surface antigen 8B (CS8B) of enterotoxigenic Escherichia coli
por: Njoroge, Samuel M., et al.
Publicado: (2015)

Colonization factor CS30 from enterotoxigenic Escherichia coli binds to sulfatide in human and porcine small intestine
por: Von Mentzer, Astrid, et al.
Publicado: (2020)

Coli Surface Antigen 26 Acts as an Adherence Determinant of Enterotoxigenic Escherichia coli and Is Cross-Recognized by Anti-CS20 Antibodies
por: Cádiz, Leandro, et al.
Publicado: (2018)

Review: chronic and persistent diarrhea with a focus in the returning traveler
por: Duplessis, Christopher A., et al.
Publicado: (2017)

Development of a simple, rapid, and sensitive diagnostic assay for enterotoxigenic E. coli and Shigella spp applicable to endemic countries
por: Chakraborty, Subhra, et al.
Publicado: (2022)

Enterotoxigenic Escherichia coli Multilocus Sequence Types in Guatemala and Mexico
por: Nicklasson, Matilda, et al.
Publicado: (2010)

The Coli Surface Antigen CS3 of Enterotoxigenic Escherichia coli Is Differentially Regulated by H-NS, CRP, and CpxRA Global Regulators
por: Ares, Miguel A., et al.
Publicado: (2019)

Critical Needs in Advancing Shigella Vaccines for Global Health
por: MacLennan, Calman A, et al.
Publicado: (2021)

Corrigendum: Effects of lng Mutations on LngA Expression, Processing, and CS21 Assembly in Enterotoxigenic Escherichia coli E9034A
por: Saldaña-Ahuactzi, Zeus, et al.
Publicado: (2017)

Identification and characterization of the novel colonization factor CS30 based on whole genome sequencing in enterotoxigenic Escherichia coli (ETEC)
por: von Mentzer, Astrid, et al.
Publicado: (2017)

Phenotypic and genomic analyses of bacteriophages targeting environmental and clinical CS3-expressing enterotoxigenic Escherichia coli (ETEC) strains
por: Chakraborty, Sajib, et al.
Publicado: (2018)

Cell refinement of CsPbBr(3) perovskite nanoparticles and thin films
por: Tenailleau, Christophe, et al.
Publicado: (2018)

Enterotoxigenic and non-enterotoxigenic Bacteroides fragilis from fecal microbiota of children
por: Ignacio, Aline, et al.
Publicado: (2015)

Expression of Colonization Factor CS5 of Enterotoxigenic Escherichia coli (ETEC) Is Enhanced In Vivo and by the Bile Component Na Glycocholate Hydrate
por: Nicklasson, Matilda, et al.
Publicado: (2012)

Correction: Phenotypic and genomic analyses of bacteriophages targeting environmental and clinical CS3-expressing enterotoxigenic Escherichia coli (ETEC) strains
por: Chakraborty, Sajib, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_dm481ccrgr02fnph57k1i5mqdu