A longitudinal and transancestral analysis of DNA methylation patterns and disease activity in lupus patients

Epigenetic dysregulation is implicated in the pathogenesis of lupus. We performed a longitudinal analysis to assess changes in DNA methylation in lupus neutrophils over 4 years of follow-up and across disease activity levels using 229 patient samples. We demonstrate that DNA methylation profiles in...

Descripción completa

Detalles Bibliográficos
Autores principales: Coit, Patrick, Ortiz-Fernandez, Lourdes, Lewis, Emily E., McCune, W. Joseph, Maksimowicz-McKinnon, Kathleen, Sawalha, Amr H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710270/
https://www.ncbi.nlm.nih.gov/pubmed/33108347
http://dx.doi.org/10.1172/jci.insight.143654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710270/
https://www.ncbi.nlm.nih.gov/pubmed/33108347
http://dx.doi.org/10.1172/jci.insight.143654

Ejemplares similares