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A soluble activator that favors the ex vivo expansion of CD8(+)CD27(+) T cells

Adoptive cell therapy involves the infusion of tumor-reactive T cells into patients with cancer to provide antitumor immunity. The ex vivo expansion and differentiation of such T cells are key parameters that affect their therapeutic potential. Human T cells are presently expanded in culture through...

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Detalles Bibliográficos
Autores principales: Matus, Esther I., Sparkes, Amanda, Gariépy, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710272/
https://www.ncbi.nlm.nih.gov/pubmed/33208551
http://dx.doi.org/10.1172/jci.insight.141293