Metformin delays neurological symptom onset in a mouse model of neuronal complex I deficiency

Complex I (also known as NADH-ubiquinone oxidoreductase) deficiency is the most frequent mitochondrial disorder present in childhood. NADH-ubiquinone oxidoreductase iron-sulfur protein 3 (NDUFS3) is a catalytic subunit of the mitochondrial complex I; NDUFS3 is conserved from bacteria and essential f...

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Detalles Bibliográficos
Autores principales: Peralta, Susana, Pinto, Milena, Arguello, Tania, Garcia, Sofia, Diaz, Francisca, Moraes, Carlos T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710273/
https://www.ncbi.nlm.nih.gov/pubmed/33148885
http://dx.doi.org/10.1172/jci.insight.141183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710273/
https://www.ncbi.nlm.nih.gov/pubmed/33148885
http://dx.doi.org/10.1172/jci.insight.141183

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