Kras(P34R) and Kras(T58I) mutations induce distinct RASopathy phenotypes in mice

Somatic KRAS mutations are highly prevalent in many cancers. In addition, a distinct spectrum of germline KRAS mutations causes developmental disorders called RASopathies. The mutant proteins encoded by these germline KRAS mutations are less biochemically and functionally activated than those in can...

Descripción completa

Detalles Bibliográficos
Autores principales: Wong, Jasmine C., Perez-Mancera, Pedro A., Huang, Tannie Q., Kim, Jangkyung, Grego-Bessa, Joaquim, del pilar Alzamora, Maria, Kogan, Scott C., Sharir, Amnon, Keefe, Susan H., Morales, Carolina E., Schanze, Denny, Castel, Pau, Hirose, Kentaro, Huang, Guo N., Zenker, Martin, Sheppard, Dean, Klein, Ophir D., Tuveson, David A., Braun, Benjamin S., Shannon, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710308/
https://www.ncbi.nlm.nih.gov/pubmed/32990679
http://dx.doi.org/10.1172/jci.insight.140495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710308/
https://www.ncbi.nlm.nih.gov/pubmed/32990679
http://dx.doi.org/10.1172/jci.insight.140495

Ejemplares similares