Development of Site-Specific PEGylated Granulocyte Colony Stimulating Factor With Prolonged Biological Activity

Currently, amino-terminal PEGylated human granulocyte colony stimulating factor (huG-CSF) is used to prevent and treat neutropenia. Although huG-CSF has been used as a drug for more than 20 years, it has three significant drawbacks: (i) it relies on PEG aldehyde for PEGylation of the alpha-amino gro...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumari, Monika, Sahni, Girish, Datta, Sonal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710547/
https://www.ncbi.nlm.nih.gov/pubmed/33330413
http://dx.doi.org/10.3389/fbioe.2020.572077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710547/
https://www.ncbi.nlm.nih.gov/pubmed/33330413
http://dx.doi.org/10.3389/fbioe.2020.572077

Ejemplares similares