Predicting favorable landing pads for targeted integrations in Chinese hamster ovary cell lines by learning stability characteristics from random transgene integrations

Chinese Hamster Ovary (CHO) cell lines are considered to be the preferred platform for the production of biotherapeutics, but issues related to expression instability remain unresolved. In this study, we investigated potential causes for an unstable phenotype by comparing cell lines that express sta...

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Detalles Bibliográficos
Autores principales: Dhiman, Heena, Campbell, Marguerite, Melcher, Michael, Smith, Kevin D., Borth, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710658/
https://www.ncbi.nlm.nih.gov/pubmed/33304461
http://dx.doi.org/10.1016/j.csbj.2020.11.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710658/
https://www.ncbi.nlm.nih.gov/pubmed/33304461
http://dx.doi.org/10.1016/j.csbj.2020.11.008

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