Telomeric injury by KML001 in human T cells induces mitochondrial dysfunction through the p53-PGC-1α pathway

Telomere erosion and mitochondrial dysfunction are prominent features of aging cells with progressive declines of cellular functions. Whether telomere injury induces mitochondrial dysfunction in human T lymphocytes, the major component of adaptive host immunity against infection and malignancy, rema...

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Detalles Bibliográficos
Autores principales: Schank, Madison, Zhao, Juan, Wang, Ling, Li, Zhengke, Cao, Dechao, Nguyen, Lam Nhat, Dang, Xindi, Khanal, Sushant, Nguyen, Lam Ngoc Thao, Thakuri, Bal Krishna Chand, Ogbu, Stella C., Lu, Zeyuan, Zhang, Jinyu, Wu, Xiao Y., Morrison, Zheng D., El Gazzar, Mohamed, Ning, Shunbin, Moorman, Jonathan P., Yao, Zhi Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710715/
https://www.ncbi.nlm.nih.gov/pubmed/33268822
http://dx.doi.org/10.1038/s41419-020-03238-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710715/
https://www.ncbi.nlm.nih.gov/pubmed/33268822
http://dx.doi.org/10.1038/s41419-020-03238-7

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