The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression

A repertoire of T cells with diverse antigen receptors is selected in the thymus. However, detailed mechanisms underlying this thymic positive selection are not clear. Here we show that the CCR4-NOT complex limits expression of specific genes through deadenylation of mRNA poly(A) tails, enabling pos...

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Detalles Bibliográficos
Autores principales: Ito-Kureha, Taku, Miyao, Takahisa, Nishijima, Saori, Suzuki, Toru, Koizumi, Shin-ichi, Villar-Briones, Alejandro, Takahashi, Akinori, Akiyama, Nobuko, Morita, Masahiro, Naguro, Isao, Ishikawa, Hiroki, Ichijo, Hidenori, Akiyama, Taishin, Yamamoto, Tadashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710727/
https://www.ncbi.nlm.nih.gov/pubmed/33268794
http://dx.doi.org/10.1038/s41467-020-19975-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710727/
https://www.ncbi.nlm.nih.gov/pubmed/33268794
http://dx.doi.org/10.1038/s41467-020-19975-4

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