Mannan-MOG35-55 Reverses Experimental Autoimmune Encephalomyelitis, Inducing a Peripheral Type 2 Myeloid Response, Reducing CNS Inflammation, and Preserving Axons in Spinal Cord Lesions

CNS autoantigens conjugated to oxidized mannan (OM) induce antigen-specific T cell tolerance and protect mice against autoimmune encephalomyelitis (EAE). To investigate whether OM-peptides treat EAE initiated by human MHC class II molecules, we administered OM-conjugated murine myelin oligodendrocyt...

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Detalles Bibliográficos
Autores principales: Dagkonaki, Anastasia, Avloniti, Maria, Evangelidou, Maria, Papazian, Irini, Kanistras, Ioannis, Tseveleki, Vivian, Lampros, Fotis, Tselios, Theodore, Jensen, Lise Torp, Möbius, Wiebke, Ruhwedel, Torben, Androutsou, Maria-Eleni, Matsoukas, John, Anagnostouli, Maria, Lassmann, Hans, Probert, Lesley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711156/
https://www.ncbi.nlm.nih.gov/pubmed/33329540
http://dx.doi.org/10.3389/fimmu.2020.575451

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711156/
https://www.ncbi.nlm.nih.gov/pubmed/33329540
http://dx.doi.org/10.3389/fimmu.2020.575451

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