Computational Modeling of NLRP3 Identifies Enhanced ATP Binding and Multimerization in Cryopyrin-Associated Periodic Syndromes

Cyropyrin-associated periodic syndromes (CAPS) are clinically distinct syndromes that encompass a phenotypic spectrum yet are caused by alterations in the same gene, NLRP3. Many CAPS cases and other NLRP3-autoinflammatory diseases (NLRP3-AIDs) are directly attributed to protein-coding alterations in...

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Detalles Bibliográficos
Autores principales: Samson, Jenny Mae, Ravindran Menon, Dinoop, Vaddi, Prasanna K., Kalani Williams, Nazanin, Domenico, Joanne, Zhai, Zili, Backos, Donald S., Fujita, Mayumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711157/
https://www.ncbi.nlm.nih.gov/pubmed/33329557
http://dx.doi.org/10.3389/fimmu.2020.584364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711157/
https://www.ncbi.nlm.nih.gov/pubmed/33329557
http://dx.doi.org/10.3389/fimmu.2020.584364

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