HARP: a database of structural impacts of systematic missense mutations in drug targets of Mycobacterium leprae

Computational Saturation Mutagenesis is an in-silico approach that employs systematic mutagenesis of each amino acid residue in the protein to all other amino acid types, and predicts changes in thermodynamic stability and affinity to the other subunits/protein counterparts, ligands and nucleic acid...

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Detalles Bibliográficos
Autores principales: Vedithi, Sundeep Chaitanya, Malhotra, Sony, Skwark, Marcin J., Munir, Asma, Acebrón-García-De-Eulate, Marta, Waman, Vaishali P, Alsulami, Ali, Ascher, David B, Blundell, Tom L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711215/
https://www.ncbi.nlm.nih.gov/pubmed/33304465
http://dx.doi.org/10.1016/j.csbj.2020.11.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711215/
https://www.ncbi.nlm.nih.gov/pubmed/33304465
http://dx.doi.org/10.1016/j.csbj.2020.11.013

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