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HARP: a database of structural impacts of systematic missense mutations in drug targets of Mycobacterium leprae
Computational Saturation Mutagenesis is an in-silico approach that employs systematic mutagenesis of each amino acid residue in the protein to all other amino acid types, and predicts changes in thermodynamic stability and affinity to the other subunits/protein counterparts, ligands and nucleic acid...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Research Network of Computational and Structural Biotechnology
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711215/ https://www.ncbi.nlm.nih.gov/pubmed/33304465 http://dx.doi.org/10.1016/j.csbj.2020.11.013 |