Accelerated production of α2,8- and α2,9-linked polysialic acid in recombinant Escherichia coli using high cell density cultivation

Polysialic acid (polySia) are α2,8- and/or α2,9-linked homopolymers with interesting properties for meningococcal vaccine development or the cure of human neurodegenerative disorders. With the goal to avoid large scale production of pathogenic bacteria, we compare in the current study the efficacy o...

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Detalles Bibliográficos
Autores principales: Bartling, Bastian, Brüchle, Nora C., Rehfeld, Johanna S., Boßmann, Daniel, Fiebig, Timm, Litschko, Christa, Fohrer, Jörg, Gerardy-Schahn, Rita, Scheper, Thomas, Beutel, Sascha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711218/
https://www.ncbi.nlm.nih.gov/pubmed/33304838
http://dx.doi.org/10.1016/j.btre.2020.e00562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711218/
https://www.ncbi.nlm.nih.gov/pubmed/33304838
http://dx.doi.org/10.1016/j.btre.2020.e00562

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