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Structural and Biophysical Insights into the TCRαβ Complex in Chickens
In this work, chicken HPAIV H5N1 epitope-specific TCRαβ (ch-TCRαβ) was isolated and its structure was determined. The Cα domain of ch-TCRαβ does not exhibit the typical structure of human TCRαβ, and the DE loop extends outward, resulting in close proximity between the Cα domain of ch-TCRαβ and CD3εδ...
Autores principales: | Zhang, Lijie, Liu, Yanjie, Meng, Geng, Liang, Ruiying, Zhang, Bing, Xia, Chun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711287/ https://www.ncbi.nlm.nih.gov/pubmed/33305184 http://dx.doi.org/10.1016/j.isci.2020.101828 |
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