Intranasal Delivery of a Chitosan-Hydrogel Vaccine Generates Nasal Tissue Resident Memory CD8(+) T Cells That Are Protective against Influenza Virus Infection

Rapid antigen clearance from the nasal mucosa is one of the major challenges in the development of intranasal vaccines. Here, we tested whether intranasal immunization with a chitosan-hydrogel vaccine, with in situ gelling properties, extended antigen retention time within the nasal mucosa. Intranas...

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Detalles Bibliográficos
Autores principales: Bedford, James G., Caminschi, Irina, Wakim, Linda M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712318/
https://www.ncbi.nlm.nih.gov/pubmed/33019568
http://dx.doi.org/10.3390/vaccines8040572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712318/
https://www.ncbi.nlm.nih.gov/pubmed/33019568
http://dx.doi.org/10.3390/vaccines8040572

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