Cargando…

DNA methylation patterns of β-globin cluster in β-thalassemia patients

BACKGROUND: Reactivation of fetal hemoglobin (HbF, α(2)γ(2)) holds a therapeutic target for β-thalassemia and sickle cell disease. Although many HbF regulators have been identified, the methylation patterns in β-globin cluster driving the fetal-to-adult hemoglobin switch remains to be determined. RE...

Descripción completa

Detalles Bibliográficos
Autores principales: Bao, Xiuqin, Zuo, Yangjin, Chen, Diyu, Zhao, Cunyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712619/
https://www.ncbi.nlm.nih.gov/pubmed/33272312
http://dx.doi.org/10.1186/s13148-020-00987-2