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DNA methylation patterns of β-globin cluster in β-thalassemia patients

BACKGROUND: Reactivation of fetal hemoglobin (HbF, α(2)γ(2)) holds a therapeutic target for β-thalassemia and sickle cell disease. Although many HbF regulators have been identified, the methylation patterns in β-globin cluster driving the fetal-to-adult hemoglobin switch remains to be determined. RE...

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Detalles Bibliográficos
Autores principales:	Bao, Xiuqin, Zuo, Yangjin, Chen, Diyu, Zhao, Cunyou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712619/ https://www.ncbi.nlm.nih.gov/pubmed/33272312 http://dx.doi.org/10.1186/s13148-020-00987-2

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