Cargando…

rAAV-Mediated Overexpression of SOX9 and TGF-β via Carbon Dot-Guided Vector Delivery Enhances the Biological Activities in Human Bone Marrow-Derived Mesenchymal Stromal Cells

Scaffold-assisted gene therapy is a highly promising tool to treat articular cartilage lesions upon direct delivery of chondrogenic candidate sequences. The goal of this study was to examine the feasibility and benefits of providing highly chondroreparative agents, the cartilage-specific sex-determi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meng, Weikun, Rey-Rico, Ana, Claudel, Mickaël, Schmitt, Gertrud, Speicher-Mentges, Susanne, Pons, Françoise, Lebeau, Luc, Venkatesan, Jagadeesh K., Cucchiarini, Magali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712756/ https://www.ncbi.nlm.nih.gov/pubmed/32354138 http://dx.doi.org/10.3390/nano10050855

Ejemplares similares

Enhanced Chondrogenic Differentiation Activities in Human Bone Marrow Aspirates via sox9 Overexpression Mediated by pNaSS-Grafted PCL Film-Guided rAAV Gene Transfer
por: Venkatesan, Jagadeesh K., et al.
Publicado: (2020)

rAAV-mediated overexpression of TGF-β stably restructures human osteoarthritic articular cartilage in situ
por: Venkatesan, Jagadeesh K, et al.
Publicado: (2013)

Effects of combined rAAV-mediated TGF-β and sox9 gene transfer and overexpression on the metabolic and chondrogenic activities in human bone marrow aspirates
por: Tao, Ke, et al.
Publicado: (2017)

Impact of mechanical stimulation on the chondrogenic processes in human bone marrow aspirates modified to overexpress sox9 via rAAV vectors
por: Venkatesan, Jagadeesh K., et al.
Publicado: (2017)

Effects of rAAV-Mediated sox9 Overexpression on the Biological Activities of Human Osteoarthritic Articular Chondrocytes in Their Intrinsic Three-Dimensional Environment
por: Daniels, Oliver, et al.
Publicado: (2019)

TGF‐β gene transfer and overexpression via rAAV vectors stimulates chondrogenic events in human bone marrow aspirates
por: Frisch, Janina, et al.
Publicado: (2016)

Co-overexpression of TGF-β and SOX9 via rAAV gene transfer modulates the metabolic and chondrogenic activities of human bone marrow-derived mesenchymal stem cells
por: Tao, Ke, et al.
Publicado: (2016)

Remodeling of Human Osteochondral Defects via rAAV-Mediated Co-Overexpression of TGF-β and IGF-I from Implanted Human Bone Marrow-Derived Mesenchymal Stromal Cells
por: Morscheid, Stephanie, et al.
Publicado: (2019)

Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-β and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells
por: Morscheid, Stephanie, et al.
Publicado: (2019)

rAAV-mediated overexpression of TGF-β via vector delivery in polymeric micelles stimulates the biological and reparative activities of human articular chondrocytes in vitro and in a human osteochondral defect model
por: Rey-Rico, Ana, et al.
Publicado: (2017)

Improved Chondrogenic Differentiation of rAAV SOX9-Modified Human MSCs Seeded in Fibrin-Polyurethane Scaffolds in a Hydrodynamic Environment
por: Venkatesan, Jagadeesh K., et al.
Publicado: (2018)

Effects of rAAV-mediated FGF-2 gene transfer and overexpression upon the chondrogenic differentiation processes in human bone marrow aspirates
por: Frisch, Janina, et al.
Publicado: (2016)

Peripheral blood aspirates overexpressing IGF‐I via rAAV gene transfer undergo enhanced chondrogenic differentiation processes
por: Frisch, Janina, et al.
Publicado: (2017)

Therapeutic Delivery of rAAV sox9 via Polymeric Micelles Counteracts the Effects of Osteoarthritis-Associated Inflammatory Cytokines in Human Articular Chondrocytes
por: Urich, Jonas, et al.
Publicado: (2020)

Controlled Release of rAAV Vectors from APMA-Functionalized Contact Lenses for Corneal Gene Therapy
por: Alvarez-Rivera, Fernando, et al.
Publicado: (2020)

rAAV Vectors as Safe and Efficient Tools for the Stable Delivery of Genes to Primary Human Chondrosarcoma Cells In Vitro and In Situ
por: Madry, Henning, et al.
Publicado: (2012)

rAAV TGF-β and FGF-2 Overexpression via pNaSS-Grafted PCL Films Stimulates the Reparative Activities of Human ACL Fibroblasts
por: Amini, Mahnaz, et al.
Publicado: (2023)

Influence of carbonization conditions on luminescence and gene delivery properties of nitrogen-doped carbon dots
por: Mickaël, Claudel, et al.
Publicado: (2019)

Influence of insulin-like growth factor I overexpression via recombinant adeno-associated vector gene transfer upon the biological activities and differentiation potential of human bone marrow-derived mesenchymal stem cells
por: Frisch, Janina, et al.
Publicado: (2014)

Correction: Influence of carbonization conditions on luminescence and gene delivery properties of nitrogen-doped carbon dots
por: Claudel, Mickaël, et al.
Publicado: (2019)

SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells
por: Venkatesan, Jagadeesh K, et al.
Publicado: (2012)

Genetic Modification of Human Peripheral Blood Aspirates Using Recombinant Adeno‐Associated Viral Vectors for Articular Cartilage Repair with a Focus on Chondrogenic Transforming Growth Factor‐β Gene Delivery
por: Frisch, Janina, et al.
Publicado: (2016)

Robust Long-term Transduction of Common Marmoset Neuromuscular Tissue With rAAV1 and rAAV9
por: Okada, Hironori, et al.
Publicado: (2013)

Current perspectives in stem cell research for knee cartilage repair
por: Orth, Patrick, et al.
Publicado: (2014)

Combined In Vitro and In Vivo Approaches to Propose a Putative Adverse Outcome Pathway for Acute Lung Inflammation Induced by Nanoparticles: A Study on Carbon Dots
por: Weiss, Maud, et al.
Publicado: (2021)

Scaffold-Mediated Gene Delivery for Osteochondral Repair
por: Madry, Henning, et al.
Publicado: (2020)

Differential effects of two MRI contrast agents on the integrity and distribution of rAAV2 and rAAV5 in the rat striatum
por: Osting, Sue, et al.
Publicado: (2014)

Translational applications of photopolymerizable hydrogels for cartilage repair
por: Meng, Weikun, et al.
Publicado: (2019)

rAAV8 and rAAV9-Mediated Long-Term Muscle Transduction with Tacrolimus (FK506) in Non-Human Primates
por: Ishii, Akiko, et al.
Publicado: (2020)

Extracorporeal Delivery of rAAV with Metabolic Exchange and Oxygenation
por: Bieber, Scott, et al.
Publicado: (2013)

rAAV-delivered PTEN therapeutics for prostate cancer
por: Ai, Jianzhong, et al.
Publicado: (2021)

TGF-β1 and TIMP1 double directional rAAV targeted by UTMD in atherosclerotic vulnerable plaque
por: Su, Yijin, et al.
Publicado: (2017)

Immunomodulation in Administration of rAAV: Preclinical and Clinical Adjuvant Pharmacotherapies
por: Chu, Wing Sum, et al.
Publicado: (2021)

Monobac System–A Single Baculovirus for the Production of rAAV
por: Galibert, Lionel, et al.
Publicado: (2021)

Durability of transgene expression after rAAV gene therapy
por: Muhuri, Manish, et al.
Publicado: (2022)

Performance of Cardiotropic rAAV Vectors Is Dependent on Production Method
por: Rao, Renuka, et al.
Publicado: (2022)

Subcellular distribution of the rAAV genome depends on genome structure
por: Oh, Nuri, et al.
Publicado: (2023)

Cytotoxic effects of different mouthwash solutions on primary human articular chondrocytes and normal human articular cartilage – an in vitro study
por: Cai, Xiaoyu, et al.
Publicado: (2023)

rAAV-compatible MiniPromoters for restricted expression in the brain and eye
por: de Leeuw, Charles N., et al.
Publicado: (2016)

Computational and molecular tools for scalable rAAV-mediated genome editing
por: Stoimenov, Ivaylo, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_dfsvsn6pu8m7n4u0bp1kfl0nor