DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity

Upon sensing cytosolic DNA, the enzyme cGAS induces innate immune responses that underpin anti-microbial defenses and certain autoimmune diseases. Missense mutations of PRKDC encoding the DNA-dependent protein kinase (DNA-PK) catalytic subunit (DNA-PKcs) are associated with autoimmune diseases, yet...

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Detalles Bibliográficos
Autores principales: Sun, Xiaona, Liu, Ting, Zhao, Jun, Xia, Hansong, Xie, Jun, Guo, Yu, Zhong, Li, Li, Mi, Yang, Qing, Peng, Cheng, Rouvet, Isabelle, Belot, Alexandre, Shu, Hong-Bing, Feng, Pinghui, Zhang, Junjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712783/
https://www.ncbi.nlm.nih.gov/pubmed/33273464
http://dx.doi.org/10.1038/s41467-020-19941-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712783/
https://www.ncbi.nlm.nih.gov/pubmed/33273464
http://dx.doi.org/10.1038/s41467-020-19941-0

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