Cargando…

Molecular Modeling of the Shigella flexneri Serogroup 3 and 5 O-Antigens and Conformational Relationships for a Vaccine Containing Serotypes 2a and 3a

The pathogenic bacterium Shigella flexneri is a leading global cause of diarrheal disease. The O-antigen is the primary vaccine target and distinguishes the 30 serotypes reported. Except for serotype 6, all S. flexneri serotypes have a common backbone repeating unit (serotype Y), with variations in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hlozek, Jason, Owen, Sara, Ravenscroft, Neil, Kuttel, Michelle M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712985/ https://www.ncbi.nlm.nih.gov/pubmed/33147882 http://dx.doi.org/10.3390/vaccines8040643

Ejemplares similares

Conformational and Immunogenicity Studies of the Shigella flexneri Serogroup 6 O-Antigen: The Effect of O-Acetylation
por: Richardson, Nicole Inge, et al.
Publicado: (2021)

Conformation and Cross-Protection in Group B Streptococcus Serotype III and Streptococcus pneumoniae Serotype 14: A Molecular Modeling Study
por: Kuttel, Michelle M., et al.
Publicado: (2019)

Modeling of pneumococcal serogroup 10 capsular polysaccharide molecular conformations provides insight into epitopes and observed cross-reactivity
por: Richardson, Nicole I., et al.
Publicado: (2022)

The evolutionary history of Shigella flexneri serotype 6 in Asia
por: Mai, Si-Nguyen T., et al.
Publicado: (2021)

Comparison and Optimization of Quantification Methods for Shigella flexneri Serotype 6 O-antigen Containing Galacturonic Acid and Methyl-Pentose
por: Raso, Maria Michelina, et al.
Publicado: (2021)

Identification and Characterization of a Novel Shigella flexneri Serotype Yv in China
por: Sun, Qiangzheng, et al.
Publicado: (2013)

Identification of critical residues of the serotype modifying O-acetyltransferase of Shigella flexneri
por: Thanweer, Farzaana, et al.
Publicado: (2012)

Antimicrobial Resistance of Shigella flexneri Serotype 1b Isolates in China
por: Cui, Xianyan, et al.
Publicado: (2015)

Prevalence and antimicrobial resistance of Shigella flexneri serotype 2 variant in China
por: Cui, Xianyan, et al.
Publicado: (2015)

Evaluation of Molecular Serotyping Assays for Shigella flexneri Directly on Stool Samples
por: Liu, Jie, et al.
Publicado: (2021)

A Novel Plasmid-Encoded Serotype Conversion Mechanism through Addition of Phosphoethanolamine to the O-Antigen of Shigella flexneri
por: Sun, Qiangzheng, et al.
Publicado: (2012)

Characterization and immunogenicity of a Shigella flexneri 2a O-antigen bioconjugate vaccine candidate
por: Ravenscroft, Neil, et al.
Publicado: (2019)

Rapid generation of Shigella flexneri GMMA displaying natural or new and cross-reactive O-Antigens
por: Gasperini, Gianmarco, et al.
Publicado: (2022)

Isolation and genomic characterization of SfI, a serotype-converting bacteriophage of Shigella flexneri
por: Sun, Qiangzheng, et al.
Publicado: (2013)

Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a
por: Nie, Huan, et al.
Publicado: (2006)

Shigella Flexneri bacteremia in Adult
por: Sharma, Shweta, et al.
Publicado: (2012)

Genesis of a novel Shigella flexneri serotype by sequential infection of serotype-converting bacteriophages SfX and SfI
por: Sun, Qiangzheng, et al.
Publicado: (2011)

Activation of Shigella flexneri type 3 secretion requires a host-induced conformational change to the translocon pore
por: Russo, Brian C., et al.
Publicado: (2019)

Serotype-conversion in Shigella flexneri: identification of a novel bacteriophage, Sf101, from a serotype 7a strain
por: Jakhetia, Richa, et al.
Publicado: (2014)

Complete Genome Sequence of SfII, a Serotype-Converting Bacteriophage of the Highly Prevalent Shigella flexneri Serotype 2a
por: George, Divya T., et al.
Publicado: (2013)

Molecular modeling provides insights into the loading of sialic acid‐containing antigens onto CRM(197): the role of chain flexibility in conjugation efficiency and glycoconjugate architecture
por: Kuttel, Michelle M., et al.
Publicado: (2021)

GMMA and Glycoconjugate Approaches Compared in Mice for the Development of a Vaccine against Shigella flexneri Serotype 6
por: Raso, Maria Michelina, et al.
Publicado: (2020)

tmRNA Is Essential in Shigella flexneri
por: Ramadoss, Nitya S., et al.
Publicado: (2013)

Shigella flexneri perinephric abscess and bacteremia
por: Al Soub, Hussam, et al.
Publicado: (2005)

Development of Shigella conjugate vaccines targeting Shigella flexneri 2a and S. flexneri 3a using a simple platform-approach conjugation by squaric acid chemistry
por: Kelly, Meagan, et al.
Publicado: (2023)

Cysteine-Dependent Conformational Heterogeneity of Shigella flexneri Autotransporter IcsA and Implications of Its Function
por: Qin, Jilong, et al.
Publicado: (2022)

Plasmids of Shigella flexneri serotype 1c strain Y394 provide advantages to bacteria in the host
por: Parajuli, Pawan, et al.
Publicado: (2019)

Newly Emerged Serotype 1c of Shigella flexneri: Multiple Origins and Changing Drug Resistance Landscape
por: Parajuli, Pawan, et al.
Publicado: (2020)

Structures of the Shigella flexneri Type 3 Secretion System Protein MxiC Reveal Conformational Variability Amongst Homologues
por: Deane, Janet E., et al.
Publicado: (2008)

Bacteriophages are the major drivers of Shigella flexneri serotype 1c genome plasticity: a complete genome analysis
por: Parajuli, Pawan, et al.
Publicado: (2017)

Bacteriophage Sf6 host range mutant that infects Shigella flexneri serotype 2a(2) strains
por: Teh, Min Yan, et al.
Publicado: (2022)

Shigella flexneri serotype 1c derived from serotype 1a by acquisition of gtrIC gene cluster via a bacteriophage
por: Tang, Swee-Seong, et al.
Publicado: (2016)

Conformational comparisons of Pasteurella multocida types B and E and structurally related capsular polysaccharides
por: Richardson, Nicole I, et al.
Publicado: (2023)

Transient Suppression of Shigella flexneri Type 3 Secretion by a Protective O-Antigen-Specific Monoclonal IgA
por: Forbes, Stephen J., et al.
Publicado: (2011)

Molecular and Cellular Mechanisms of Shigella flexneri Dissemination
por: Agaisse, Hervé
Publicado: (2016)

Interactions between Shigella flexneri and the Autophagy Machinery
por: Krokowski, Sina, et al.
Publicado: (2016)

Characterization of a serologically atypical Shigella flexneri Z isolated from diarrheal patients in Bangladesh and a proposed serological scheme for Shigella flexneri
por: Shahnaij, Mohammad, et al.
Publicado: (2018)

Molecular characterization and analysis of high-level multidrug-resistance of Shigella flexneri serotype 4s strains from China
por: Yang, Chaojie, et al.
Publicado: (2016)

Virulence genes expression profiling of different Shigella flexneri serotypes in response to sub-inhibitory concentrations of azithromycin and ciprofloxacin
por: Sadredinamin, Mehrzad, et al.
Publicado: (2022)

Clonal serotype 1c multidrug-resistant Shigella flexneri detected in multiple institutions by sentinel-site sequencing
por: Ko, Karrie K. K., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2rjc4lmeh3qtroen91udlp82o5