Proline-rich tyrosine kinase 2 mediates transforming growth factor-beta-induced hepatic stellate cell activation and liver fibrosis

Hepatic fibrogenesis is characterized by activation of hepatic stellate cells (HSCs) and accumulation of extracellular matrix (ECM). The impact of ECM on TGF-β-mediated fibrogenic signaling pathway in HSCs has remained obscure. We studied the role of non-receptor tyrosine kinase focal adhesion kinas...

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Detalles Bibliográficos
Autores principales: Kim, Jonghwa, Kang, Wonseok, Kang, So Hee, Park, Su Hyun, Kim, Ji Young, Yang, Sera, Ha, Sang Yun, Paik, Yong-Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713048/
https://www.ncbi.nlm.nih.gov/pubmed/33273492
http://dx.doi.org/10.1038/s41598-020-78056-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713048/
https://www.ncbi.nlm.nih.gov/pubmed/33273492
http://dx.doi.org/10.1038/s41598-020-78056-0

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